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NMN Administration: a Novel Therapeutic Direction for Sepsis-induced Acute Lung Injury
NMN Administration: a Novel Therapeutic Direction for Sepsis-induced Acute Lung Injury

1. Introduction Acute lung injury comprises a uniform response of the lung to inflammatory or chemical insults which is commonly caused by systemic illness including sepsis or trauma, infection with pathogens, and tox

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Probing the Magic Role of NAD+ Metabolism-associated Genes in Gastric Cancer
Probing the Magic Role of NAD+ Metabolism-associated Genes in Gastric Cancer

  1. Introduction Gastric cancer (GC) represents a global health-care challenge, which is the fifth most common cancer and the fourth leading cause of cancer death across the world in 2020, with a significant

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A Scientific Method for Quantifying NMN in Biological Samples
A Scientific Method for Quantifying NMN in Biological Samples

1. Introduction Supplementation of nicotinamide mononucleotide (NMN) to upregulate the level of nicotinamide adenine dinucleotide (NAD+) has been unveiled to be a promising anti-aging intervention. However, it is

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The Nuanced Role of NADPH in the Complex Landscape of Metabolic Disorders
The Nuanced Role of NADPH in the Complex Landscape of Metabolic Disorders

1.Introduction Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), also known as reduced coenzyme II, is a critical cofactor in cellular antioxidant systems and lipid synthesis, which links insulin

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Extraordinary Merits of Ultrasensitive ELISA with Thio-NAD Cycling in Determining Dengue NS1 Protein
Extraordinary Merits of Ultrasensitive ELISA with Thio-NAD Cycling in Determining Dengue NS1 Protein

1. Introduction Dengue fever is an acute infectious disease caused by the Dengue virus through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito, with the main symptoms such as hi

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How to Reconcile the Axonal Degeneration Caused by NMN Accumulation with the Anti-ageing Effect of NMN
How to Reconcile the Axonal Degeneration Caused by NMN Accumulation with the Anti-ageing Effect of NMN

1. Introduction The NAD precursor nicotinamide mononucleotide (NMN) shows a beneficial effect on ageing, yet excessive NMN accumulation may lead to axon degeneration. How to make the anti-ageing

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The Miraculous Potency of NR-CL on Mitigating Ischemia-induced Hippocampal Damage and Maintaining Cognitive Function
The Miraculous Potency of NR-CL on Mitigating Ischemia-induced Hippocampal Damage and Maintaining Cognitive Function

  1 Introduction Nicotinamide riboside (NR), a derivative of vitamin B3, is a new type of bioactive substance, which can be generated by binding a carbohydrate molecular ribose with nicotinamide (a

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Deciphering Another Mechanism of Action for NMN Administration: Improving Lysosomal Ferroptosis to Prevent Heart Failure
Deciphering Another Mechanism of Action for NMN Administration: Improving Lysosomal Ferroptosis to Prevent Heart Failure

1. Introduction      Heart failure is a serious condition in the development of cardiovascular disease. In particular, diastolic heart failure, as one of the most common manifestations of heart failure in

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Health Upgrade: Focus on the Therapeutic Effect of Ginsenoside Rh2
Health Upgrade: Focus on the Therapeutic Effect of Ginsenoside Rh2

1. Introduction Ginseng has always been highly perceived as a valuable traditional Chinese medicine in China. Currently, much attention also has been paid to ginsenosides, the main active ingredients extracted from g

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